Nucleoside (acid) and its derivatives have a very broad application prospect in medicine, health products, food processing industry, plant growth, and prevention of diseases and insect pests, and have been highly valued by many developed countries. Noticeably, with the development of gene therapy (e.g., siRNA, mRNA, plasmids, aptamers), different functionalized polynucleotides will be discovered gradually and make a great benefit to the health of humankind. Besides, regarding the trend of social aging, nucleic acid health products with anti-aging effects will be more remarkable.
On the basis, there are three technologies to build nucleoside (acid) products, i.e.the high efficient catalytic synthesis technology, the nucleoside fermentation technology, and biotransformation semi-synthesis technology. The products include pyrimidine series, purine series, nucleotide series, nucleoside series, such as citicoline sodium, ribavirin, inosine, acyclovir, cytosine, 5-fluorocytosine, cytidine, and other raw materials and pharmaceutical intermediates. The pharmaceutical APIs cover the fields of antiviral, antineoplastic, and nervous system drugs. The detailed products with different certain certificates of chemicals and pharmaceutics (e.g., ISO9001, GMP, DMF, REACH) or nutrition (e.g., HALAL, KOSHER) are shown below, which can be supported by ASCHEM (www.aschem.ch).
| Nucleoside (acid) and its derivatives | |||
| Products | CAS No. | ||
| Purine | |||
| Hypoxanthine | 68-94-0 | ||
| 6-Chloropurine | 87-42-3 | ||
| Adenine | 73-24-5 | ||
| 2,6-Dichloropurine | 5451-40-1 | ||
| 6-Benzylaminopurine | 1214-39-7 | ||
| 6-Furfurylaminopurine | 525-79-1 | ||
| Azathioprine | 446-86-6 | ||
| 6-Chloropurine THP | 7306-68-5 | ||
| N,9-Diacetylguanine | 3056-33-5 | ||
| Dicacetyl-Aciclovir | 75123-73-3 | ||
| Pyrimidine | |||
| Cytosine | 71-30-7 | ||
| N4-Acetylcytosine | 14631-20-0 | ||
| N4-Benzoylcytosine | 26661-13-2 | ||
| 5-Fluorocytosine | 2022-85-7 | ||
| 5-Azacytosine | 931-86-2 | ||
| Uracil | 66-22-8 | ||
| Nucleoside | |||
| Adenosine | 58-61-7 | ||
| Cytidine | 65-46-3 | ||
| Uridine | 58-96-8 | ||
| 5-Fluorocytidine | 2341-22-2 | ||
| 5-Azacytidine | 320-67-2 | ||
| Guanosine | 118-00-3 | ||
| 2,6-Dichloropurine Ribose | 13276-52-3 | ||
| 2-Aminoadenosine | 2096-10-08 00:00:00 | ||
| 2-Chloroadenosine | 146-77-0 | ||
| 2-Iodoadenosine | 35109-88-7 | ||
| 6-Chloroguanosine | 2004-07-01 00:00:00 | ||
| 2',3'-O-Isopropylidene adenosine | 362-75-4 | ||
| 6-Chloropurine Riboside | 2004-06-0 | ||
| 5'-Tosyladenosine | 5135-30-8 | ||
| Capecitabine | 154361-50-9 | ||
| Isoprinosine | 36703-88-5 | ||
| S-Adenosylmethionine 1,4-butanedisulfonate | 101020-79-5 | ||
| Arabinosyl nucleosides | |||
| Arabinoadenosine | 5536-17-4 | ||
| Arabinoguanosine | 38819-10-2 | ||
| Arabinofuranosyluracil | 3083-77-0 | ||
| Arabinofuranosylcytosine | 147-94-4 | ||
| Fludarabine | 21679-14-1 | ||
| 2,6-Amino-arabinoadenosine | 34079-68-0 | ||
| Nelarabine | 121032-29-9 | ||
| Fludarabine phosphate | 75607-67-9 | ||
| 2' (or and 3')-Deoxy nucleosides | |||
| 2'-Deoxyadenosine | 958-09-8 | ||
| 2'-Deoxyguanosine monohydrate | 961-07-9 | ||
| 2'-Deoxycytidine | 951-77-9 | ||
| 2'-Deoxyuridine | 951-78-0 | ||
| 5-Iodo-2'-Deoxyuridine | 54-42-2 | ||
| 5-methyl-2'-Deoxycytidine | 838-07-3 | ||
| Clofarabine | 123318-82-1 | ||
| 3'-Deoxyadenosine (cordycepin) | 73-03-0 | ||
| 2,3'-Dideoxyuridine | 9/5/ 5983-9-5 | ||
| Cyclo-nucleosides | |||
| CMC·HCl | 51391-96-9 | ||
| 2,2'-O-Cyclouridine | 3736-77-4 | ||
| Cyclocytidine hydrochloride | 10212-25-6 | ||
| 2'-Methyoxy(or 2'- Fluoro) nucleosides | |||
| 2'-Methyoxy uridine | 2140-76-3 | ||
| 5-Methyl-2'-Methyoxy uridine | 55486-09-4 | ||
| 2'-Deoxy-2'-Fluorouridine | 784-71-4 | ||
| 2'-Deoxy-2'-Fluorocytidine | 10212-20-1 | ||
| Nucleotides | |||
| Cytidine-5' monophosphate, free acid | 63-37-6 | ||
| Adenosine5'-monophosphate,free acid | 61-19-8 | ||
| Cytidine-5'-monophosphate Disodium Salt | 229-819-3 | ||
| Adenosine5'-monophosphate Sodium Salt | 13474-03-8 | ||
| Adenosine5'-monophosphate Disodium Salt | 4578-31-8 | ||
| Uridine-5'-monophosphate Disodium Salt | 3387-36-8 | ||
| Citicoline | 987-78-0 | ||
| 2'-Deoxy Nucleotides | |||
| 2'-Deoxyguanosine- 5'-monophosphate disodium salt | 33430-61-4 | ||
| 2'-Deoxyadenosine -5'-monophosphate Disodium salt | 2922-74-9 | ||
| 2'-Deoxyuridine-5'-monophosphate Disodium salt | 42155-08-8 | ||
| 2'-Deoxycytidine-5'-monophosphate Disodium salt | 13085-50-2 | ||
| 2'-Deoxyguanosine-5'-Phosphate Free acid | 902-04-5 | ||
| 2'-Deoxyuridine-5'-monophosphate Free acid | 964-26-1 | ||
| 2'-Deoxyadenosine-5'-monophosphate Free acid | 653-63-4 | ||
| 2'-Deoxycytidine-5'-monophosphate Free acid | 1032-65-1 | ||
| Sugar (furanose) | |||
| D-ribose | 58-61-7 | ||
| Tetraacetylribofuranose | 13035-61-5 | ||
| 2-Deoxy-2-fluoro-1,3,5-tri-O-benzoyl-D-ribofuranose | 97614-43-2 | ||
| 1-Chloro-3,5-Di-(p-Chlorobenzoyl)-2-Deoxy-D-Ribose | 3601-90-9 | ||
| 1-O-Acetyl-2,3,5-Tri-D-Benzoyl -β-D-Ribose | 6974-32-9 | ||
| 1,3,5-Tri-O-benzoyl-D-ribofuranose | 22224-41-5 | ||
| 1,2,3-Triacetyl-5-Deoxy-D-Ribose | 62211-93-2 | ||
| API | |||
| Vidarabine monophosphate | 29984-33-6 | ||
| Cytarabine hydrochloride | 69-74-9 | ||
| Ribavirin | 36791-04-5 | ||
| Inosine | 58-63-9 | ||
| Citicoline Sodium | 33818-15-4 | ||
| Acyclovir | 59277-89-3 |